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以聚类法儿童中间型β地中海贫血的中医证候分布规律

发布时间:2013-10-10 13:36:33  

中华中医药杂志(原中国医药学报)2012年3月第27卷第3期 CJTCMP,March 2012,Vol.27,No.3? 607 ?

·论著·

以聚类分析法研究儿童中间型β地中海贫血的

中医证候分布规律

卢焯明1,2,钱新华3

(1南方医科大学,广州 510515;2广州市中医医院,广州 510130;3南方医科大学南方医院,

广州 510515)

摘要:目的:探讨儿童中间型β地中海贫血患者的证候分布规律。方法:制定“中医证候临床观察表”,对106例儿童中间型β地中海贫血患者进行中医证候调查,并检测相关血液学指标,建立SPSS 13.0统计数据库,运用聚类分析等统计学方法,结合临床确定其证候分布特点。结果:聚类分析结果聚为4类,分别为气血两虚证(42.5%)、肝肾阴虚证(36.8%)、脾肾阳虚证(15.1%)、阴阳两虚证(5.7%)。肝肾阴虚证的血红蛋白水平高于阴阳两虚证,差异有统计学意义(P<0.05)。结论:在广州地区的中间型β地中海贫血患儿中,中医证候分布特点为气血两虚证>肝肾阴虚证>脾肾阳虚证>阴阳两虚证,为进一步规范化辨证论治提供了一定依据。

关键词:聚类分析;地中海贫血;证候分布规律

基金资助:广东省中医药局科研课题(No.2010285)

Study on distribution regularity of TCM syndromes in children with β-thalassemia

intermedia using cluster analysis

LU Zhuo-ming1,2, QIAN Xin-hua3

( 1Southern Medical University, Guangzhou 510515, China; 2Guangzhou Hospital of TCM, Guangzhou 510130, China;

3Nanfang Hospital, Southern Medical University, Guangzhou 510515, China )

Abstract: Objective: To explore the distribution regularity of TCM syndromes in children with β-thalassemia intermedia. Methods: This study made the Clinical Observation Form of TCM Syndromes with thalassemia, investigated the TCM syndromes of 106 children cases with β-thalassemia intermedia and tested their related hematology measures. All data were established the data based by SPSS 13.0 statistical software. The distribution of TCM syndromes pattern was analyzed by cluster analysis and other methods. Results: The TCM syndromes in children with β-thalassemia intermedia were characterized four syndromes patterns: de? ciency of qi and blood (42.5%), de? ciency of liver-yin and kidney-yin (36.8%), de? ciency of spleen-yang and kidney-yang (15.1%), and de? ciency of yin and yang (5.7%). The HGB values of the patients with de? ciency of liver-yin and kidney-yin syndrome were signi? cantly higher than those of the patients with de? ciency of yin and yang(P<0.05). Conclusion: The distribution of TCM syndromes pattern in children with β-thalassemia intermedia in Guangzhou area is de? ciency of qi and blood syndrome>de? ciency of liver-yin and kidney-yin>de? ciency of spleen-yang and kidney-yang>de? ciency of yin and yang. This study can offer some references to the further normative treatment of children with β-thalassemia intermedia based on TCM syndromes differentiation.

Key words: Cluster analysis; Thalassemia; Distribution regularity of TCM syndromes

Fund assistance: Research Program of Administration of TCM of Guangdong Province (No.2010285)

地中海贫血是严重危害人类健康尤其是儿童及

青少年健康成长的遗传性血液疾病。我国是地中海

贫血的高发区,在南方各省如广东、广西、云南、贵

州、海南等发病率较高。目前重型和中间型β地中海

贫血的治疗仍以输血配合去铁治疗为主,二者均较

昂贵且有较多副作用。相对于西药,传统中医药副作用较小,目前以中医药治疗β地中海贫血已初显疗效,但仍是以个案报道、一般性临床观察或基础研究居多,大样本规范的临床研究较少,尤其运用现代统计学手段对儿童β地中海贫血中医证候分布规律方面的研究更是鲜见报道。本研究对来自于广东地区的106例中间型β地中海贫血患儿进行中医证候调通讯作者:卢焯明,广州市珠玑路广州市中医医院住院部9楼儿科,邮编:510130,电话:020-81226093,E-mail:lzmloots@yahoo.com.cn

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