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德之馨-儿童护理产品方案

发布时间:2013-12-11 15:00:50  

Jun 2009 Presented by

Cosmetic Ingredients Scent & Care Division Asia-Pacific

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Baby Care

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Baby Care

? SymRelief SymCalmin ? Hydroviton 24 Symdiol-68

? Flowerpones

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Baby Care

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Baby Care

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Baby Care

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SymRelief (170015) -

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Hydroviton-24 (610391) Neo PCL W/S (674260) , Extrapone Anti-Mic (168505) 18

-

SymRelief
SymRelief : 0.1 to 0.2 %

170015

IL-1 PGE2

(

); );

.

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Hydroviton? 24
24
,

610391

Placebo 1% HYDROVITON 24 2% HYDROVITON 24

Corneometer delta values (c.u.)

P
: 1-2%

6.0 5.0 4.0 3.0 2.0 1.0 0.0 -1.0 1h

3

6

Time (hours)

12

24

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NEO PCL WATER SOLUBLE N

674260

: ,

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Extrapone? AntiMic

168505

1.0% 168505, Extrapone? AntiMic

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Baby Care

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Baby Care

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Baby Care

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Emulsiphos (677660) PEG Drocorin GOC ( 683541) Hydroviton-24 (610391) Symdiol-68 (108580) SymCalmin (143535) -

O/W

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ACTIVE INGREDIENTS

SymCalmin

143535

?
SymCalmin 5% INCI: : 0.1-2.0%

??

D
O N H HO

COOH

Hydroxyphenyl Propamidobenzoic Acid

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100 80 60 40 20 0 0.5ppm 5ppm 50ppm

D
74

P

87

60 19
500ppm

Histamine net release Percentage of solvent control
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Symdiol 68
– – – – – pH pH
– – – – – – –

108580

INCI: 1,2-

( )

Sample EC PA

2D SA

CA

AN

7D EC PA SA

CA

AN

28D EC PA SA CA

AN

Anionic placebo 3 mil 10 mil 100 1.8 mil 180,000 - test stopped Anionic w 0.5 S68 0 0 100 30,000 160,000 0 0 0 Anionic w 1.0 S68 0 0 200 100 120,000 0 0 0 Anionic w 1.5 S68 0 0 0 0 13,000 0 0 0

Symdiol 68
0 0 0 100,000 0 40,000 0 100 0 0 0 0 0 0 0 0 0 0 14,000 1,000 0

Non-ionic placebo 1.4 mil 1 mil 100 240,000 160,000 - test stopped 1 Non-ionic w 0.5 S68 0 0 9,000 19,000 220,000 0 0 1,300 1,200 182,000 0 Non-ionic w 1.0 S68 0 0 200 0 130,000 0 0 0 0 91,000 0

0 0

0 0

0 140,000 0 22,000

Initial count: EC - 300,000; PA 320,000; SA - 310,000; CA 310,000; AN - 280,000

Anionic and Non-ionic Emulsions

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Emulsiphos
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677660

:

pH

(4-9)

pH

INCI: : O/W

O/W

:

, 1.0 - 3.0%, 0.2 - 0.5%
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Baby Care

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Baby Care

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DRACORIN GOC
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683541

PEG

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DRACORIN GOC
( ? ? ? ? ? ? ? PH 4-9 PEG ) :

683541

(10-40%)

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Baby Care

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Baby Care

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Baby Care

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SymRelief (170015) Zinc Oxide PI (100233) (USP30 , BP, Ph. Eur.) Flowerconcentrole 42

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Zinc Oxide PI
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100233

ZnO
29 , BP ,

DAB , Ph. Eur.

:
) : UV

(USP

(

)

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, (min. 99.8%)
? ? ? Sum (As, Hg) < 1 ppm Pb < 10 ppm Cu < 10 ppm Cr < 1 ppm Cd <10 ppm Mn <10 ppm

:

? : . 400 nm ? pH : 7.5 - 8.0 ? INCI: Zinc Oxide

K

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Baby Care

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Baby Care

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Baby Care

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Baby Care

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Baby Care

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Baby Care

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Baby Care

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SymCalmin (143535) -

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Extrapone Honeysuckle Flower (102906) ( )

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Jin Yin Hua
Extrapone Honeysuckle Flower (102906) Lonicera japonica (Thunb)

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IL-1 alpha [pg/well] 70 PGE2 [pg/well] w/o stim. 1% 0.1% 0% 60 50 40 30 20 10 0 Extrapone? Honeysuckle Flower (Jin Yin Hua) 100 80 60 40 20 0 w/o stim. 0.1% 0.01% 0.001% 0% Extrapone? Honeysuckle Flower (Jin Yin Hua)

=> 40 % inhibition of IL-1α at 1.0 %*;

20 % inhibition of PGE2 at 0.001 - 0.1 %*
* relative to stimulated control

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Baby Care

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Baby Care

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Baby Care

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/ /
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Baby Care

SymRelief (170015) SymCalmin (143535)

Extrapone Honeysuckle Flower (JinYin Hua - 102906) Flowerpones Emollients Emulsifiers Zinc Oxide

Hydroviton 24 (610391) Symdiol-68 (108580)

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THANK YOU

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